The effects of Klonopin and Xanax also manifest at different times in the body. Klonopin is a long-acting benzodiazepine with a half-life of around 30 to 40 hours. It reaches peak concentrations within one to four hours of ingestion, while its effects last up to 12 hours. Hence, it doesn’t have to be dosed as frequently as other short-acting benzodiazepines.
Xanax is a short-acting benzodiazepine with a half-life of about 11.2 hours. It reaches peak levels in the blood within one to two hours of administration, while its effects last up to four to six hours. Hence, Xanax needs frequent administration to keep blood levels constant.
Klonopin is available as both generic and orally disintegrating tablets (wafers) in various strengths:
- Oral tablets – 0.5 mg, 1 mg, and 2 mg
- Orally disintegrating tablets – 1.125 mg, 0.25 mg, 0.5 mg, 1 mg, and 2 mg
A typical starting dose of Klonopin for panic disorder is 0.25 mg, taken twice daily. If the dose is insufficient to treat your symptoms, your healthcare provider may increase your dose every few days up until the maximum recommended daily dose of 4 mg.
In contrast, Xanax is available in many forms and strengths:
- Disintegrating tablets – 0.25 mg, 0.5 mg, 1 mg, and 2 mg
- Immediate-release tablets – 0.25 mg, 0.5 mg, 1 mg, and 2 mg
- Extended-release tablets – 0.5 mg, 1 mg, 2 mg, and 3 mg
- Oral liquid – 1 mg/ml
For generalized anxiety disorder, a typical starting dose of Xanax is 0.25 to 0.5 mg, taken three times per day, while the maximum recommended daily dose is 4 mg (in divided doses). On the other hand, the typical starting dose for panic disorder is 0.5 mg, taken three times per day, while the maximum recommended daily dose is 10 mg.